Abstract #1192
Importance of Biexponential T2* and Partial Volume Effect Corrections on Quantification of Sodium Concentrations and Fixed Charge Density of Articular Cartilage with 23 Na-MRI at 7T
Lasse P. Rsnen 1 , Stefan Zbyn 2 , Miika T. Nieminen 3,4 , Eveliina Lammentausta 3 , Xeli Deligianni 5,6 , Oliver Bieri 5 , Siegfried Trattnig 2 , and Rami Korhonen 1
1
Department of Applied Physics, University of
Eastern Finland, Kuopio, Finland,
2
MR
Centre-High Field MR, Department of Biomedical Imaging
and Image-Guided Therapy, Medical University of Vienna,
Vienna, Austria,
3
Department
of Diagnostic Radiology, Oulu University Hospital, Oulu,
Finland,
4
Department
of Radiology, University of Oulu, Oulu, Finland,
5
Division
of Radiological Physics Department of Radiology,
University of Basel Hospital, Basel, Switzerland,
6
Merian
Iselin Klinik, Basel, Switzerland
The importance of the biexponential decay of the
transverse relaxation of sodium (
23
Na) and
the signal attenuation due to partial volume effect
(PVE) were investigated, while determining
23
Na
concentration and FCD of the tibial and femoral
cartilage tissues with MRI. The use of biexponential
signal correction together with PVE increased the
23
Na
concentrations up to +179%, thus also enabling the
quantification of FCD of cartilage. The results suggest
that biexponential signal decay and PVE can be notable
even at 7T and relatively small resolution and should be
considered when quantifying
23
Na
content and FCD from
23
Na-MRI.
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