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Abstract #1193

Reduction of magic angle effect for quantitative MRI of articular cartilage in vivo

Mikko Johannes Nissi 1,2 , Victor Casula 1,2 , Eveliina Lammentausta 2,3 , Shalom Michaeli 4 , Silvia Mangia 4 , Edward Auerbach 4 , Jutta Ellermann 4 , and Miika T Nieminen 1,3

1 Department of Radiology, Institute of Diagnostics, University of Oulu, Oulu, Finland, 2 Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland, 3 Department of Radiology, Oulu University Hospital, Oulu, Finland, 4 CMRR, Department of Radiology, University of Minnesota, Minneapolis, MN, United States

Magic angle effect is a major confounding factor in both quantitative and qualitative assessment of articular cartilage, as well as of other tissues. Recently, reduced magic angle dependence was demonstrated for adiabatic T 1 lower case Greek rho relaxation time in articular cartilage. In this work, adiabatic T 1 lower case Greek rho and T 2 relaxation time constants of human knee articular cartilage were measured in vivo at 3 T. Adiabatic T 1 lower case Greek rho relaxation time maps demonstrated reduced magic angle effect in cartilage regions at susceptible angles as compared to T 2 relaxation time. Adiabatic T 1 lower case Greek rho technique provides a promising alternative to T 2 for the assessment of articular cartilage.

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