Abstract #1141
Characterization of Invasive Breast Cancer using Quantitative DCE-MRI at 3.0T
Reem Bedair 1 , Martin Graves 2 , Mary McLean 3 , Scott Reid 4 , Roie Manavaki 1 , John Griffiths 3 , Andrew Patterson 2 , and Fiona Gilbert 1
1
University of Cambridge, Department of
Radiology, Cambridge, Cambridgeshire, United Kingdom,
2
Department
of Radiology, Cambridge University Hospitals NHS
Foundation Trust, Cambridge, Cambridgeshire, United
Kingdom,
3
Cancer
Research UK Cambridge Research Institute, Cambridge,
Cambridgeshire, United Kingdom,
4
GE
Healthcare, Diagnostic Imaging, Buckingham,
Buckinghamshire, United Kingdom
DCE-MRI has proven a promising non-invasive modality for
characterizing the pathophysiological microenvironment
of tumours. Pharmacokinetic modelling can yield results
of tumour-vessel permeability, perfusion and
extracellular-extravascular volume fraction. This work
exploits the improved spatiotemporal resolution
achievable at 3.0T to investigate the relationship
between the modelled vascular parameters and their
histopathological profile within a cohort of breast
cancer patients. Hotspot Ktrans and ve were found to be
higher for the more common malignant types. A
significant difference was found between hotspot Ktrans
and ve in grades 1 and 3 tumours. Our results indicate
that Ktrans and ve provide important and independent
information concerning tumor biology and microvascular
structure that supports the use of these more complex
analysis protocols.
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