Abstract #1140
A Practical Approach to Pharmacokinetic Modelling in monitoring Neoadjuvant Chemotherapy in Breast Cancer
Reem Bedair 1 , Andrew Patterson 2 , Mary McLean 3 , Roie Manavaki 1 , Scott Reid 4 , John Griffiths 3 , Martin Graves 2 , and Fiona Gilbert 1
1
University of Cambridge, Department of
Radiology, Cambridge, Cambridgeshire, United Kingdom,
2
Department
of Radiology, Cambridge University Hospitals NHS
Foundation Trust, Cambridge, Cambridgeshire, United
Kingdom,
3
Cancer
Research UK Cambridge Research Institute, Cambridge,
Cambridgeshire, United Kingdom,
4
GE
Healthcare, Diagnostic Imaging, Buckingham,
Buckinghamshire, United Kingdom
Quantitative DCE-MRI together with pharmacokinetic
modelling enables the assessment of tumour-vessel
permeability and leakage space in vivo. This work
compares the early changes in the PK-derived parameter
(Ktrans ) using both a voxel-wise histogram analysis
across the entire tumour and the average Ktrans from the
largest slice in cohort of breast cancer patients
undergoing neoadjuvant chemotherapy. Although
pixel-based analyses can demonstrate significant
differences in the distribution of Ktrans, this can be a
time-consuming process. Our results show that the
average Ktrans calculated from the single largest slice
provides statistically similar results that can be
easily incorporated into routine clinical practice.
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