Abstract #1139
Assessment of Background Parenchymal Enhancement in Breast MRI of BRCA 1/2 Mutation Carriers Compared to Matched Controls
Alana Amarosa Lewin 1 , Sungheon Kim 1 , James S Babb 1 , Amy N Melsaether 1 , Jason McKellop 1 , Melanie Moccaldi 2 , Ana Paula Klautau Leite 3 , and Linda Moy 1
1
Radiology, New York University School of
Medicine, New York, New York, United States,
2
Radiology,
New York University Cancer Institute, New York, New
York, United States,
3
Radiology,
Hospital das Clnicas, School of Medicine, University of
So Paulo, Brazil
This study investigates whether quantitative kinetic
analysis of benign lesions and background parenchyma
(BP) in breast MRI can elucidate differences between
BRCA carriers and sporadic controls with high risk for
breast cancer. We identified 49 BRCA mutation carriers
and 49 control cases with benign lesions for comparison
of their initial and delayed enhancement ratios (IER and
DER) of BP. The control group showed significant
differences in IER and DER between pre and
post-menopausal women, but the BRCA group did not. Our
results also indicate that the BRCA gene mutation has
multifactorial and complex clinical and biologic
implications.
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