Abstract #1103
MRI accurately identifies early murine mammary cancers and reliably differentiates between in situ and invasive cancer: Correlation of MRI with histology
Devkumar Mustafi 1 , Erica Markiewicz 1 , Marta Zamora 1 , Xiaobing Fan 1 , Jeffrey Mueller 2 , Suzanne D Conzen 3 , and Gregory S Karczmar 1
1
Radiology, The University of Chicago,
Chicago, IL, United States,
2
Pathology,
The University of Chicago, Chicago, IL, United States,
3
Medicine,
Section of Hematology and Oncology, The University of
Chicago, Chicago, IL, United States
Precise MRI-histopathology correlation demonstrates that
MRI accurately identifies mammary cancer at various
stages of development in the widely used C3(1)SV40Tag
mouse model, and provides a tool for the development of
image-based markers that differentiate indolent from
aggressive cancer. 96% of
in
situ
and
100% of invasive cancers identified on
in
vivo
MRI
agreed with histology. Methods described here will allow
investigators to develop better MRI-based markers for
tumor progression, improve understanding of cancer
initiation and progression, evaluate response to therapy
in murine models of breast cancer, and provide valuable
insights regarding clinical management of patients with
early breast cancers.
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