Abstract #1102
MR characterization of a syngeneic orthotopic ovarian tumor model
Marie-France Penet 1 , Balaji Krishnamachary 1 , Flonn Wildes 1 , Yelena Mironchik 1 , Chien-Fu Hung 2 , TC Wu 2 , and Zaver M Bhujwalla 1
1
JHU ICMIC Program, Division of Cancer
Imaging Research, The Russell H Morgan Department of
Radiology, The Johns Hopkins University School of
Medicine, Baltimore, MD, United States,
2
Department
of Pathology, The Johns Hopkins University School of
Medicine, Baltimore, MD, United States
Epithelial ovarian cancer remains the leading cause of
death from gynecologic malignancy among women in
developed countries. Identifying mechanisms that drive
the aggressiveness of ovarian cancers and its associated
pathologies, such as the formation of metastases and the
build-up of ascitic fluid, is urgently needed to provide
new targets in effective control and treatment.
Noninvasive magnetic resonance imaging (MRI) and
magnetic resonance spectroscopic imaging (MRSI) provide
opportunities to characterize the tumor microenvironment
and to assess its relationship with ascites and
metastases. We applied MRI and MRSI to better
characterize ascites formation in a syngeneic orthotopic
experimental model of ovarian cancer.
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