Abstract #1104
Validation of anti-VEGF Therapy in a Radiation Necrosis Mouse Model
Carlos J Perez-Torres 1 , Liya Yuan 2 , Robert E Schmidt 3 , Keith M Rich 2 , Robert E Drzymala 4 , Joseph JH Ackerman 1,5 , and Joel R Garbow 1
1
Radiology, Washington University, Saint
Louis, MO, United States,
2
Neurosurgey,
Washington University, Saint Louis, MO, United States,
3
Neuropathology,
Washington University, Saint Louis, MO, United States,
4
Radiation
Oncology, Washington University, Saint Louis, MO, United
States,
5
Chemistry,
Washington University, Saint Louis, MO, United States
The use of anti-VEGF antibodies represents a new
treatment approach for radiation necrosis. We present a
timeline of VEGF expression and test the effectiveness
and specificity of anti-VEGF antibody treatment in our
mouse model of radiation necrosis. While the anti-VEGF
antibody treatment has an effect on the extent of
injury, it does not reduce VEGF expression. The
persistence of VEGF could lead to the recurrence of
injury once treatment is stopped.
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