Abstract #0891
Quantitative Sodium Imaging of Breast Tumors at 7 Tesla: preliminary results
Olgica Zaric 1 , Katja Pinker - Domenig 2 , Stefan Zbyn 1 , Thomas Helbich 2 , Alex Farr 3 , Christian Singer 3 , Siegfried Trattnig 1 , and Wolfgang Bogner 1
1
High Field MR Center, Department of
Biomedical Imaging and Image-guided Therapy, Medical
University of Vienna, Vienna, Austria,
2
Department
of Biomedical Imaging and Image-guided Therapy, Medical
University of Vienna, Vienna, Austria,
3
Gynecology
Department, Medical University of Vienna, Vienna,
Austria, Austria
Tissue sodium concentration (TSC) could be considered as
a sensitive biomarker that provides non-invasive
information on the changes in malignant tissue such as
angiogenesis and cellular proliferation. The aim of this
study was to investigate the feasibility of quantitative
high-resolution sodium (23Na)- MRI in breast tumor
patients at 7.0 T. Reproducible good image quality in
clinically feasible time was achieved. Our results
showed excellent differentiation between breast lesions
(TSC showed 40% higher values in malignant then in
benign tumors). We believe that 23Na combined with other
MRI techniques, has a great potential in breast tumors
detection and characterization.
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