Abstract #0890
7T Breast MRI to Visualize Proliferative Characteristics of Breast Cancer using DCE, DWI, and 31 P-MRS
Alexander M. Th. Schmitz 1 , Wouter B. Veldhuis 1 , Marian B.E. Menke-Pluijmers 2 , Wybe J.M. van der Kemp 1 , Tijl A. van der Velden 1 , Marc C.J.M. Kock 3 , Pieter J. Westenend 4 , Dennis W.J. Klomp 1 , and Kenneth G.A. Gilhuijs 1
1
Department of Radiology/Image Sciences
Institute, University Medical Center Utrecht, Utrecht,
Netherlands,
2
Department
of Surgery, Albert Schweitzer Hospital, Dordrecht,
Netherlands,
3
Department
of Radiology, Albert Schweitzer Hospital, Dordrecht,
Netherlands,
4
Department
of Pathology, Albert Schweitzer Hospital, Dordrecht,
Netherlands
Breast cancer therapy would benefit from more accurate
tumor characterization early in therapy, especially
concerning tumor proliferation. MRI may provide
additional information early in treatment. In-vivo
characterization using DWI and MRS may be beneficial,
but the ability of 1.5 and 3T MRI systems to provide
clinically useful information is limited by their
sensitivity. In this study, a 7T breast MRI
multi-protocol was developed including DCE-MRI, DWI and
31
P-MRS.
Fifteen women were included with 17 malignant lesions.
First explorations in correlation with histopathology
show potential of DWI and
31
P-MRS
to visualize biomarkers of tumor proliferation.
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