Abstract #0399
Brain Magnetic Susceptibility is Increased with Cognitive Impairment in a Community Population
Armin Eilaghi 1,2 , D Adam McLean 3 , Cheryl R. McCreary 1,2 , David Gobbi 3 , M Louis Lauzon 1,2 , Marina Salluzzi 3 , Eric E Smith 1,2 , and Richard Frayne 1,2
1
Radiology and Clinical Neurosciences,
Hotchkiss Brain Institute, University of Calgary,
Calgary, Alberta, Canada,
2
Seaman
Family MR Centre, Foothills Medical Centre, Calgary,
Alberta, Canada,
3
Calgary
Image Processing and Analysis Centre, Foothills Medical
Centre, Calgary, Alberta, Canada
We demonstrated that susceptibility obtained with QSM
was significantly higher in the cognitively impaired
group than the normal group, after controlling for age
in a cohort of volunteers drawn from the community. This
proof-of-concept study underscores the potential value
of susceptibility to distinguish cognition decline at
the early, pre-symptomatic phase.
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