Abstract #0398
Cortical volume and perfusion are influenced by vascular risk factors in addition to cognitive status: new insight made available from the ADNI study
Ekaterina Tchistiakova 1,2 and Bradley J. MacIntosh 1,2
1
Medical Biophysics, University of Toronto,
Toronto, ON, Canada,
2
Heart
and Stroke Foundation Canadian Partnership for Stroke
Recovery, Sunnybrook Research Institute, Toronto, ON,
Canada
Recent studies demonstrated that vascular risk factors
(VRFs) increase the risk of AD. Little, however, is
known on the interaction of AD progression and VRF
burden and their impact on brain health. In this study
we used a multivariate approach to examine the impact of
VRFs on the cortical volume in normal controls and MCI
groups. Our results indicate that cortical volume
variability is predominantly driven by MCI individuals
with high VRF burden. Our secondary analysis showed no
association between cortical volumes and cerebral blood
flow in those groups, but it was apparent in MCI
individuals with low VRF burden.
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