Abstract #0397
Increased cortical volume revealed by atlas-based volumetry in a bigenic mouse model of Alzheimer's Disease
Kristof Govaerts 1 , Janaki Raman Rangarajan 2 , Tom Struys 3 , Fred Van Leuven 4 , Uwe Himmelreich 1 , and Tom Dresselaers 1
1
Imaging & Pathology, KU Leuven, Leuven,
Vlaams-Brabant, Belgium,
2
Electrical
Engineering, KU Leuven, Leuven, Vlaams-Brabant, Belgium,
3
Morphology,
Universiteit Hasselt, Hasselt, Limburg, Belgium,
4
Human
Genetics, KU Leuven, Leuven, Vlaams-Brabant, Belgium
Although atrophy is a well-established biomarker for
Alzheimers Disease (AD) in human patients, MRI-based
studies on this subject in mice are scarce. Here, we
made use of an atlas-based registration protocol, and we
show that the bigenic biAT mouse model displays
increased rather than decreased cortical volume, both at
3 and at 12 months of age. Differences were small but
highly significant. Histological assessment also showed
decreased neuronal density in the frontal cortex.
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