Abstract #0400
Regional cerebral iron concentrations as indicated by magnetic susceptibilities measured with Quantitative Susceptibility Mapping (QSM) at 7 Tesla correlate with brain Aβ plaque density as measured by 11-C-Pittsburgh Compound B Positron-Emission-Tomography (PiB-PET) in elderly subjects at risk for Alzheimers disease (AD)
Jiri M.G. van Bergen 1,2 , Xu Li 2 , Michael Wyss 3 , Simon J. Schreiner 1 , Stefanie C. Steininger 1 , Anton F. Gietl 1 , Valerie Treyer 1,4 , Sandra E. Leh 1 , Fred Buck 4 , Jun Hua 2 , Roger Nitsch 1 , Klaas P. Pruessmann 3 , Peter C.M. van Zijl 2 , Christoph Hock 1 , and Paul G. Unschuld 1
1
Division of Psychiatry Research and
Psychogeriatric Medicine, University of Zurich, Zurich,
Zurich, Switzerland,
2
F.M.
Kirby center for Functional Brain Imaging, Kennedy
Krieger Institute and Johns Hopkins School of Medicine,
Baltimore, Maryland, United States,
3
Institute
for Biomedical Engineering, University of Zurich and ETH
Zurich, Zurich, Switzerland,
4
Division
of Nuclear Medicine, University of Zurich, Zurich,
Switzerland
In subjects with Mild Cognitive Impairment it was shown
that susceptibility values as measured by Quantitative
Susceptibility Mapping (QSM) correlate with A
plaque
density as measured by 11-C-Pittsburgh Compound B
Positron-Emission-Tomography (PiB-PET). Susceptibility
in gray matter has been shown to relate to tissue iron
content. Correlations were observed in the frontal,
parietal, temporal and occipital cortices and the
caudate nucleus. The correlation was driven by carriers
of the Apolipoprotein E gene, an Alzheimers Disease
(AD) associated risk factor. Our results suggest that
cerebral iron accumulation may reflect A
associated
brain dysfunction in subjects at increased risk for late
onset AD.
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