Abstract #0280
Magnetic susceptibilities measured by Quantitative Susceptibility Mapping (QSM) indicate brain iron levels correlate with genetic burden in prodromal Huntington's disease
Jiri M.G. van Bergen 1,2 , Jun Hua 1,2 , Paul G. Unschuld 3,4 , Issel Anne L. Lim 1,2 , Craig K. Jones 1,2 , Russell L. Margolis 4,5 , Christopher A. Ross 4,5 , Peter C.M. van Zijl 1,2 , and Xu Li 1,2
1
Radiology, Johns Hopkins School of Medicine,
Baltimore, Maryland, United States,
2
F.M.
Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, Maryland, United
States,
3
Division
of Psychiatry Research and Psychogeriatric Medicine,
University of Zurich, Zurich, Zurich, Switzerland,
4
Psychiatry
and Behavioral Sciences, Johns Hopkins School of
Medicine, Baltimore, Maryland, United States,
5
Neurology,
Johns Hopkins School of Medicine, Baltimore, Maryland,
United States
Using Quantitative Susceptibility Mapping (QSM) on
subjects with prodromal Huntingtons disease we found
altered magnetic susceptibility in basal ganglia
structures of the brain, as compared to controls.
Increases were seen in caudate nucleus, putamen, and
globus pallidus, while decreases were observed in
hippocampus and substantia nigra. Susceptibility levels
in the caudate and putamen correlated with the an
estimate of time to onset of manifest HD. Changes in
susceptibility in gray matter have been shown to relate
to tissue iron content. Our data thus indicate potential
clinical relevance of iron as a biomarker of disease
progression.
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