Abstract #0281
Quantitative Susceptibility Mapping of Lesions in Multiple Sclerosis
Ahmed M. Elkady 1 , Hongfu Sun 1 , Andrew J. Walsh 1 , Gregg Blevins 2 , Zhuozhi Dai 1 , and Alan H. Wilman 1
1
Dept. of Biomedical Engineering, University
of Alberta, Edmonton, AB, Canada,
2
Division
of Neurology, University of Alberta, Edmonton, AB,
Canada
Susceptibility (SUS), Local Field Shift (LFS), and R2*
conspicuity and contrast of 351 lesions were examined in
20 Multiple Sclerosis (MS) patients. Although the
majority were not visible in SUS or LFS, visible lesions
mostly appeared as hyper-core with no ring. Perls iron
stain of 22 lesions in two postmortem MS subjects were
also examined in pathology sections and matched to
lesions conspicuity and contrast in registered in situ
MRI. Results indicated that hyper-core lesion contrast
in LFS or SUS and dipole field patterns in LFS could
confirm the presence of iron, but could not predict iron
absence.
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