Abstract #0279
Longitudinal changes of white matter following mild traumatic brain injury by diffusion, T2 and susceptibility MRI
Wei Li 1,2 , Justin Long 1 , Lora Watts 1 , Qiang Shen 1 , and Timothy Q. Duong 1,2
1
Research Imaging Institute, University of
Texas Health Science Center at San Antonio, San Antonio,
TX, United States,
2
Ophthalmology,
University of Texas Health Science Center at San
Antonio, San Antonio, TX, United States
Diffusion, T2 and magnetic susceptibility MRI were used
to characterize white matter changes following mild TBI
using a rat controlled cortical impact model. Two groups
can be differentiated based on these contrasts. The
first group showed widespread diffusion and T2 changes,
but localized susceptibility increase at day 2. The
second group showed normal contrasts at all the time
points. These results suggest that diffusion, T2 and
susceptibility MRI may provide a unique combination to
assess white matter damages, and to provide useful
information regarding the spatial-temporal evolution of
white matter edema and myelin disruptions post TBI.
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