Abstract #0278
Comparison of Cerebral Blood Flow and Arterial Transit Time mapping methods: Look-Locker ASL, Hadamard Encoded ASL, and Multi-TI ASL with Variable Bolus and TR
Megan Johnston 1 and Youngkyoo Jung 1,2
1
Biomedical Engineering, Wake Forest School
of Medicine, Winston-Salem, North Carolina, United
States,
2
Radiology,
Wake Forest School of Medicine, Winston-Salem, North
Carolina, United States
Multi-TI ASL with Variable bolus and TR ASL uses
variable post-labeling delays to enable simultaneous
arterial transit time and cerebral blood flow
estimation. Time efficiency is improved by shortening TR
for shorter TI times. Shortened labeling bolus durations
allow for shortened TI times which enables for T1 and M0
estimation from the same raw data, fitting to the
saturation recovery equation. Resulting blood flow and
transit time maps fit the perfusion model better in the
gray matter than Hadamard Encoded ASL and Look-Locker
ASL with a larger percentage of voxels having a
significant fit to the kinetic model.
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