Abstract #0237
SWI monitoring iron tagged dextran transportation in normal and hydrocephalus rat brains via intrathecal delivery
Satish Krishnamurthy 1 , Jie Li 1 , Yimin Shen 2 , and E Mark Haacke 2
1
Department of Neurosurgery, SUNY Upstate
Medical University, Syracuse, NY, United States,
2
Radiology,
Wayne state university, Detroit, MI, United States
We hypothesized that macromolecular transportation is
altered in communicating hydrocephalus rats. SWI was
used to monitoring iron tagged dextran transportation in
rat brains via intraventricular delivery. Fe-Dextran
clearance time depended on the dose. Distribution
kinetics of Fe-Dextran in cerebral ventricles and
parenchyma was clearly different in hydrocephalus rats
compared to normal rats. The tracer entering the brain
tissue via para-arterial pathways was rapidly cleared
and did not build up in the brain parenchyma or vessel
wall for normal rats while there was an obvious delay in
clearance with a significant increase in Fe-Dextran in
the veins for the hydrocephalus rats.
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