Abstract #0238
Blood-Brain-Barrier Permeability and Lesion Volume Changes in Acute Japanese Macaque Encephalomyelitis
Ian Tagge 1,2 , Steven Kohama 3 , Jim Pollaro 1 , Lawrence Sherman 3 , Dennis Bourdette 4 , Randy Woltjer 4 , Scott Wong 3 , and William Rooney 1,2
1
Advanced Imaging Research Center, Oregon
Health & Science University, Portland, Oregon, United
States,
2
Biomedical
Engineering, Oregon Health & Science University,
Portland, OR, United States,
3
Oregon
National Primate Research Center, Oregon Health &
Science University, Oregon, United States,
4
Neurology,
Oregon Health & Science University, Portland, Oregon,
United States
Dynamic-contrast-enhanced magnetic resonance imaging
(DCE-MRI) provides a unique method of quantitatively
characterizing neurovascular properties in-vivo.
Pharmacokinetic modeling of DCE-MRI data allows
quantification of vascular properties, such as BBB
permeability, that are sensitive to disease state.
Japanese Macaque Encephalomyelitis (JME) is a
spontaneous non-human primate analog of human MS. We
adopted a short-term longitudinal study design to
investigate lesion morphological and microvascular
changes in acute JME. Lesions are observed to be fairly
stable within approximately 24 hrs, but substantial
changes can occur in as few as 3 days. Acute lesions
with elevated BBB permeability arise from NABT rapidly
(< 7 days).
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