Abstract #0236
Investigation of glymphatic impairment in diabetes using MRI and distributed RC line model
Esmaeil Davoodi Bojd 1 , Li Zhang 1 , Guangliang Ding 1 , Siamak Nejad-Davarani 1 , ZhengGang Zhang 1 , Lian Li 1 , QingJiang Li 1 , Michael Chopp 1 , and Quan Jiang 1
1
Neurology, Henry Ford Health System,
Detroit, Michigan, United States
This work demonstrates the first investigation of
glymphatic impairment after diabetes in rat using MRI.
Gd-DTPA contrast agent is used to monitor the glymphatic
pathways by MR imaging. Using an equivalent electrical
circuit for the glymphatic system, the clearance rate of
CA from the brain is estimated. The results show that
the CA remains much longer in diabetic brain than normal
one. This means that the CSF moves slower in diabetic
rats. The proposed approach can be used to determine
quantitatively the effect of treatment after
neurological disorder, such as diabetes.
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