Abstract #3226
Combined Effects of Albumin and Manganese on 1H Relaxation Rates of aCSF
L. Sorina Truica 1 , J. Keiko McCreary 1 , Adam R. Neumann 1 , Maurice A. Needham 1 , Albert R. Cross 1 , and Ian Q. Whishaw 1
1
Neuroscience, University of Lethbridge,
Lethbridge, Alberta, Canada
The use of manganese (Mn) as a contrast agent for neuro-anatomical
and functional mapping has been studied in animal models
for the last decade. Mn contrast enhancement is directly
proportional to the changes in relaxation rates in brain
tissue. However, the binding of Mn to proteins may alter
its relaxation. Thus protein levels and metabolic
processes that produce them in the brain and
cerebrospinal fluid (CSF) will alter Mn contrast. The
aim of this study was to investigate the relaxation rate
of Mn in artificial CSF (aCSF), when different levels of
protein are present. We found that the concentration of
protein used affected both the T1 and T2 relaxation
times.
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