Abstract #3227
Voxel-based quantitative MRI in multiple sclerosis
Maria Engstrm 1,2 , Jan B M Warntjes 2,3 , Anders Tisell 2,4 , Anne-Marie Landtblom 2,5 , and Peter Lundberg 2,4
1
Radiology, Linkping University, Linkping,
Sweden,
2
Center
for Medical Image Science and Visualization (CMIV),
Linkping University, Linkping, Sweden,
3
Clinical
Physiology, Linkping University, Linkping, Sweden,
4
Radiation
Physics, Linkping University, Linkping, Sweden,
5
Neurology,
Linkping University, Linkping, Sweden
The purpose was to improve objective measures for brain
tissue characterization and visualization in groups
using quantitative MRI in combination with brain
normalization. Nineteen multiple sclerosis (MS) patients
and 20 healthy controls were investigated with
quantitative MRI, measuring the relaxation rates, R1 and
R2, and the proton density. Voxel-based statistical
analysis showed shared tissue aberrations in the MS
patients and aberrations that were related to MS
disability. Quantitative MRI together with voxel-based
statistical analysis and multi-parametric visualization
is an up-and-coming method to study neuropathology and
its neuroanatomical correlation to clinical disability
measures that are common for an entire group.
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