Abstract #3225

Detection of 2-Deoxy-D-Glucose in Tissues By T 1 Relaxometry

John Thomas Spear ^1,2 , Zhongliang Zu ^2,3 , and John C. Gore ^2,4

¹ Physics & Astronomy, Vanderbilt University, Nashville, TN, United States, ² Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ³ Radiology, Vanderbilt University, Nashville, TN, United States, ⁴ Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

MRI detection of 2-Deoxy-D-Glucose in tissues has the potential to allow imaging of regional metabolism. Adding 2DG to tissue should add to the background R ₁ dispersion by an amount dependent on the concentration. R ₁ dispersion was measured in rat brain tissue homogenates with various concentrations of 2DG to demonstrate this effect and show how the mean exchange rate shifts. Exchange Rate Contrast (ERC) images can be made so the image intensity scales with 2DG concentration, which is established by calculating mean pixel intensities as a function of concentration.

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