Abstract #3224

Quantifying Intrinsic Susceptibility Variations and Exchange Processes by T 1 Dispersion in Blood

John Thomas Spear ^1,2 , Zhongliang Zu ^2,3 , and John C. Gore ^2,4

¹ Physics & Astronomy, Vanderbilt University, Nashville, TN, United States, ² Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ³ Radiology, Vanderbilt University, Nashville, TN, United States, ⁴ Biomedical Engineering, Vanderbilt University, Nashville, TN, United States

The dispersion of the spin-lattice relaxation rate in the rotating frame, R ₁ , has recently been shown to be sensitive to diffusion through magnetically inhomogeneous media with internal susceptibility gradients. In most systems in vivo, chemical exchange will significantly affect this dispersion as well, especially at high field. A method to analyze both effects simultaneously has been proposed and tested using blood with varying oxygen saturation levels as a model system. The contribution of diffusion decreases with oxygen saturation as the internal gradients diminish, leaving only chemical exchange to influence R ₁ dispersion.

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