Abstract #0515

Combined Visualization of ADC Diffusion Maps and CBV Perfusion Maps in Patients with Newly Diagnosed Glioblastoma

Alexander Radbruch¹,², Kira Lutz¹, Benedikt Wiestler³, Philipp Bumer¹, Markus Graf², Ralf Floca², Wolfgang Wick³, Heinz Peter Schlemmer², Martin Bendszus¹, Sabine Heiland¹

¹Department of Neuroradiology, Heidelberg University Medical Center, Heidelberg, Germany; ²Department of Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; ³Department of Neurooncology, Heidelberg University Medical Center, Heidelberg, Germany

Areas of decreased apparent diffusion coefficient (MinADC) on diffusion MRI (DWI) and areas of increased cerebral blood volume (MaxCBV) on dynamic-susceptibility-contrast perfusion MRI (DSC) are supposed to present the most malignant parts of glioblastoma. However, it is still unclear if the identified regions on DWI and DSC overlap. We assessed 20 patients with glioblastoma with a new postprocessing technique and found an average overlap in 34.7 +/- 10.9 percent. Furthermore we found that areas of MaxCBV are located mostly in the enhancing region while areas of MinADC are located mostly in the surrounding area.