Abstract #0516

Voxel-Wise Repeatability of Apparent Diffusion Coefficient in Patients with Newly Diagnosed Glioblastoma

Pavlina Polaskova¹, Kourosh Jafari-Khouzani¹, Alexander R. Guimaraes¹, Steven M. Stufflebeam¹, Patrick Y. Wen², Tracy T. Batchelor³, Bruce R. Rosen¹, Elizabeth R. Gerstner³, Jayashree Kalpathy-Cramer¹

¹Radiology, Athinoula A. Martinos Center for Biomedical Imaging / Massachusetts General Hospital, Charlestown, MA, United States; ²Neuro-oncology, Brigham and Women's Hospital / Harvard Medical School, Boston, MA, United States; ³Neurology, Massachusetts General Hospital / Harvard Medical School, Boston, MA, United States

We assessed the voxel-wise repeatability of ADC values in patients with newly diagnosed glioblastoma in relation to functional diffusion mapping technique. Although the intra-class correlation coefficients are relatively high, the variability of the tumor values exceeds the thresholds for stable voxels, as proposed by functional diffusion mapping, suggesting the absolute thresholding be re-evaluated.