Abstract #0254

Acute Hemorrhagic Myocardial Infarction Leads to Localized Chronic Iron Deposition: A CMR Study

Avinash Kali¹,², Ivan Cokic¹, Andreas Kumar³, Richard L Q Tang¹, Sotirios A. Tsaftaris⁴, Matthias G. Friedrich⁵, Rohan Dharmakumar¹

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States; ²Department of Biomedical Engineering, University of California, Los Angeles, CA, United States; ³Qubec Heart and Lung Institute, Laval University, Qubec City, QC, Canada; ⁴Computer Science and Applications, IMT Institutions, Lucca, Italy; ⁵Montral Heart Institute, Universit de Montral, Montral, QC, Canada

The long-term fate of acute reperfusion intramyocardial hemorrhage (IMH) was studied using CMR. T2* maps and Late Gadolinium Enhancement images were acquired in patients with first STEMI at 3 days (acute) and 6 months (chronic) post-PCI, and in canines subjected to ischemia-reperfusion injury at 3 days (acute) and 56 days (chronic) post-reperfusion. Both patients and canines with acute IMH had persistent T2* losses within infarcted territories in chronic phase T2* maps. Mass spectrometry of canine myocardium showed that hemorrhagic infarctions had 10-fold higher iron content than non-hemorrhagic infarctions. In conclusion, acute IMH leads to chronic iron deposition within infarcted territories.