Abstract #0255

Quantitative T2 Mapping Visualizes Hemorrhage and Edema After Acute Myocardial Infarction in Swine

Haiyan Ding¹,², Michael Schr³,⁴, Elliot R. McVeigh², Henry Halperin⁵, M. Muz Zviman⁶, Roy Beinart⁶, Daniel A. Herzka⁷

¹Biomedical Engineering, Tsinghua University, Beijing, China; ²Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States; ³Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, United States; ⁴Philips Healthcare, Cleveland, OH, United States; ⁵Medicine, Cardiology, Johns Hopkins University, Baltimore, MD, United States; ⁶Medicine, Cardiology, Johns Hopkins School of Medicine, Baltimore, MD, United States; ⁷Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States

T2 relaxation time correlates with pathologic processes within infarcted myocardial tissue, such as edema, hemorrhage and microvascular obstruction (MVO). Recently, edema detection (T2 elevation) through quantitative mapping has been shown more robust than qualitative clinical T2 W imaging. Myocardial hemorrhage (T2 reduction) evolves secondary to severe vessel obstruction. We hypothesize that following myocardial infarction (MI) and reperfusion both variations in myocardial edema and hemorrhage are detectable and distinguishable with high resolution quantitative T2 mapping. Quantitative T2 imaging should allow for detection/segmentation of hemorrhage without the temporal variability imposed by contrast-enhanced imaging.