Mri Analysis of Brain Lesions in a Novel Mouse Model of Multiple Sclerosis

Hilit Levy¹, Yaniv Assaf¹, Dan Frenkel¹

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that leads to pathologic changes in white matter (WM). In most MS mouse models, the neurologic damage mostly affects the spinal cord with limited damage to the brain. Here we induced experimental allergic encephalomyelitis (EAE) on non-obese diabetic (NOD) mice which are known to develop spontaneous autoimmune diabetes. We characterized the progression of the disease with MRI by T1-Gd and DTI acquisitions. Brain lesions have been detected by MRI and histology in WM and in gray matter similar to the findings of MS in humans.