Yumei Yan1, Xiaodong Zhang1,
Brittany Howell2,3, Mar Sanchez2,3
1Yerkes Imaging Center, Yerkes National
Primate Research Center, Emory University, Atlanta, GA, United States; 2Psychiatry
& Behavioral Sciences, Emory School of Medicine, Atlanta, GA, United
States; 3Psychobiology Division, Yerkes National Primate Research
Center, Emory University, Atlanta, GA, United States
In
vivo Magnetic Resonance Spectroscopy (MRS) was used to investigate the
metabolic changes in basal ganglia (BG) and anterior cingulate cortex (ACC)
of adolescent rhesus monkeys with Early Life Stress (ELS). The MRS findings
suggest that ELS has an enduring impact on the brains of adolescent male
monkeys, potentially reflecting neuropathological alterations or even
neuronal loss in their BG (striatum). Males seem more vulnerable to these
long-term alterations than females, supporting previous sex differences in
vulnerability to ELS. The sex differences in Cho striatal concentrations
could be due to differences in glial cell proliferation.