Shaolin Yang1, Svetlana Chefer1,
D. Bruce Vaupel1, Xi Chen1, Pradeep K. Kurup1,
Thomas J. Ross1, Elliot A. Stein1, Yihong Yang1
1National Institute on Drug Abuse,
National Institutes of Health, Baltimore, MD, United States
A
proton magnetic resonance spectroscopy (1H-MRS) study was
performed to examine the metabolite abnormalities in the Rhesus monkeys
during the abstinence from a long history of methamphetamine (METH) self-administration.
The 1H-MRS spectral data were acquired from the frontal lobe and
striatum of Rhesus monkeys at 3T in 5 separate sessions (1-day, 1-week,
1-month, 3-month, and 6-month abstinence, respectively). Compared to the
control group (n=5), the total choline (tCho) level in the striatum is
significantly elevated during the early abstinence (up to 1 month) and
continued to be elevated after 3 months of drug withdrawal in the
METH-abstinence group (n=10).