Keigo Hikishima1,2, Kanehiro Fujiyoshi3,
Masayuki Yamada1,4, Yuji Komaki1,2, Suketaka Momoshima5,
Kazuo Yagi6, Norikazu Tamaoki1, Yoshiaki Toyama3,
Masaya Nakamura3, Hideyuki Okano2
1Central Institute for Experimental
Animals, Kasawaki, Kanagawa, Japan; 2Department of Physiology,
Keio University; 3Department of Orthopaedic Surgery, Keio
University; 4School of Health Science, Fujita Health University; 5Department
of Radiology, Keio University; 6Graduate School of Health Science,
Tokyo Metropolitan University
One
of the most recently developed DWI methodologies is q-space imaging (QSI)
which has been used to detect the size of microstructure using higher
b-values. We developed the myelin mapping protocol using QSI by focusing on
the strong restriction of water diffusion in myelin architecture. We compared
myelin mapping with histological findings in spinal cords using
dysmyelination mutant mice and monkeys with spinal cord injury. In this study
we demonstrated that myelin mapping depicts the presence of myelin in spinal
cord.