Samuel Anthony Hurley1, Pouria Mossahebi2,
Alexey A. Samsonov3, Andrew L. Alexander1,4, Sean C.L.
Deoni5, Ron Fisher6, Ian D. Duncan7, Aaron
S. Field, 23
1Medical Physics, University of
Wisconsin, Madison, WI, United States; 2Biomedical Engineering,
University of Wisconsin, Madison, WI, United States; 3Radiology,
University of Wisconsin, Madison, WI, United States; 4Psychiatry,
University of Wisconsin, Madison, WI, United States; 5Engineering,
Brown University, Providence, RI, United States; 6Waisman Lab for
Brain Imaging and Behavior, University of Wisconsin, Madison, WI, United
States; 7Medical Sciences, University of Wisconsin, Madison, WI,
United States
mcDESPOT
is a recently proposed technique which provides two-component relaxometry
using steady-state imaging. The
relative fraction of water in two microstructural compartments may be
estimated via the myelin water fraction map.
We report initial results of this technique on the shaking pup myelin
mutant. The shaking pup is a canine
model which suffers from dysmyelination without the confounding effects of
inflammation or edema, and is thus an excellent model for investigating the
sensitivity and specificity of mcDESPOT parameters to myelin content in the
brain.