Toxicological Effect of Thallium in Mice by NMR-Based Metabolic Profiling of Urine

Ritu Tyagi¹, Poonam Rana¹, Ahmad Raza Khan¹, M Memita Devi¹, Shubhra Chaturvedi², Subash Khushu¹

Thallium is a heavy metal that gets accumulated in liver and kidney after absorption and causes renal and hepatotoxicity. NMR spectroscopy based study has been conducted for identification of metabolite markers for thallium toxicity. Urine samples were collected from mice at 3, 24 and 96 hrs post injection of low and high dose of Tl2SO4. Spectral analysis showed dose dependent alterations in various metabolites involved in renal and hepatic toxicity and could be seen as early as 3 hrs post injection and may be further helpful in devising the protocol for decorporation of such harmful elements.