Sara Maria Sprinkhuizen1, Chris J. Bakker1,
Johannes H. Ippel2, Rolf Boelens2, Lambertus Wilhelmus
Bartels1
1Radiology, Image Sciences Institute,
Utrecht, Netherlands; 2Bijvoet Center for Biomolecular Research,
NMR Spectroscopy Research Group, Utrecht, Netherlands
In
fat tissue, large susceptibility-related PRFS-based temperature errors can be
expected, due to temporal changes in tissue susceptibility (χ) which
lead to non-local magnetic field changes. This affects the PRF (hence, the
measured temperature) of all water protons that experience this magnetic
field change, leading to temperature errors. In order to conclusively assess
the impact of temperature-induced χ changes on PRFS-based MRT, accurate
and precise susceptibility measurements in human tissue are a prerequisite.
We therefore measured dχ/dT of fat tissue of the human breast on a 14 T
NMR spectrometer. A dependence of 0.0051 ppm/C was found.