Noam Shemesh1, Evren zarslan2,
Peter J. Basser2, Yoram Cohen1
1School of Chemistry, Tel Aviv
University, Tel Aviv, Israel; 2Section on Tissue Biophysics and
Biomimetics, NICHD, National Institutes of Health, Bethesda, MD, United
States
Diffusion-diffraction
minima, which convey important microstructural information, vanish from the
signal decay in single-pulsed-field-gradient (s-PFG) experiments conducted on
specimens characterized by size distributions. The double-PFG (d-PFG)
methodology, an extension of s-PFG, was recently predicted to exhibit
zero-crossings (analogous to s-PFG diffusion-diffraction minima) that would
persist even when the specimen is characterized by a broad size-distribution.
We therefore studied the signal decay in both s- and d-PFG in
size-distribution phantoms consisting of water-filled microcapillaries of
various sizes. We find that the diffusion-diffraction minima in s-PFG indeed
vanish, while the zero-crossings in d-PFG indeed persist, allowing to extract
important microstructural information.