Christine
Marie Zwart1, David H. Frakes1,2, Josef P. Debbins3
1School of Biological and Health
Systems Engineering, Arizona State University, Tempe, AZ, United States; 2School
of Electrical, Computer, and Energy Engineering, Arizona State University,
Tempe, AZ, United States; 3Keller Center for Imaging Innovation,
St. Joseph's Hospital and Medical Center, Phoenix, AZ, United States
Many
diseases of the white matter are accompanied by an observable decrease in
fractional anisotropy as measured with Diffusion Tensor Imaging. This
decrease can be attributable to a general increase in extracellular space or
an absence of collinearity with respect to axon orientations. For studying the
progression of diseases such as multiple sclerosis (demyelination) and
epilepsy (disorder) we have developed a correlation based metric that
distinguishes between these processes.