Guangliang Ding1, Jieli Chen1, Michael Chopp1,2, Lian Li1, Tao Yan1,3, Esmaeil Davoodi-Bojd1, Qingjiang Li1, Chengcheng Cui1, Siamak P.N. Davarani1, and Quan Jiang1
1Neurology, Henry Ford Health System, Detroit, MI, United States, 2Physics, Oakland University, Rochester, MI, United States, 3Tianjin Geriatrics Institute, Tianjin Medical University General Hospital, Tianjin, China, People's Republic of
With a suture 2-hour occlusion and reperfusion
stroke model and a low dose Streptozotocin injection combined with a high fat
food diet diabetic model of young adult Wistar rats, longitudinal measurements
of MRI
demonstrated that bone marrow stromal cell treatment of stroke in type 2
diabetes mellitus rats, compared with the saline
treated control rats, not only significantly reduced blood-brain barrier
leakage and hemorrhagic spots starting from 1 week and 3 weeks after stroke
(p<0.05) measured by contrast enhanced T1WI with Gd-DTPA and identified by
SWI, respectively; but also significantly improves white matter remodeling after
stroke measured by DSI.
