Abstract #4365

The MIPP study: Monitoring Intracranial atherosclerotic Plaque Progression using high resolution MRI - initial results

Chengcheng Zhu¹, Xuefeng Zhang², Andrew J Degnan³, Qi Liu², Luguang Chen², Zhongzhao Teng⁴, David Saloner¹, and Jianping Lu²

¹Radiology, University of California, San Francisco, San Francisco, CA, United States, ²Radiology, Changhai Hospital, Shanghai, China, People's Republic of, ³Radilogy, University of Pittsburgh, Pittsburgh, PA, United States, ⁴Radiology, University of Cambridge, Cambridge, United Kingdom

Intracranial large artery atheroma is a major cause of stroke, however its natural history is still poorly understood. In this study we followed 63 symptomatic patients who had intracranial atherosclerotic plaque for up to 3 years. Multi-contrast black blood vessel wall MRI and clinical brain imaging were performed. Initial results included 22 patients who were followed for 6 months showed an overall plaque volume progression rate of 0.8%, however with a large standard deviation (20.1%) and range (-45.9% to 40.1%). Patients with hypertension or low HDL tended to progress faster. The feasibility of MRI for monitoring intracranial plaque pathological changes was demonstrated.

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