1Institute of Medicine and Neuroscience (INM-4), Research Centre Juelich, Juelich, Germany, 2Institute of Neuroscience and Medicine 4 (INM-4), Research centre Juelich, Juelich, Germany, 3Institute of Medicine and Neuroscience (INM-4), Research Centre Juelich, Juelich, Georgia, 4University Hospital Aachen, Aachen, Germany, 5university Hospital Aachen, Aachen, Germany