Abstract #4161

Amygdala down-regulation with fMRI neurofeedback in healthy subjects and BPD patients

Christian Paret¹, Matthias Ruf¹, Traute demirakca¹, Christian Schmahl², and Gabriele Ende¹

¹Neuroimaging, Central Institute of Mental Health, Mannheim, Germany, ²Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, Mannheim, Germany

fMRI neurofeedback on emotion-related brain activation via a brain-computer interface can improve brain self-regulation. We could show that neurofeedback is associated with amygdala down-regulation and alterations in frontolimbic functional connectivity in healthy female participants and female patients with borderline personality disorder. Real-time fMRI neurofeedback may in future help patients with severe emotion dysregulation to improve control over emotion-related brain networks.

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