Abstract #3752

Monitoring longitudinal functional reorganization of a capsular infarct rat model using resting-state fMRI

Chun-Qiang Lu¹ and Shenghong Ju^1,2

¹Southeast University, Nanjing, China, People's Republic of, ²ZhongDa Hospital, Nanjing, China, People's Republic of

Many resting-state fMRI studies in stroke patients claim that rs-fMRI measurements is behaviorally relevant. However, most of these studies enroll stoke patients with high heterogeneity. In this study, twenty-three rats underwent photothrombotic stroke lesioning in the PLIC with minimal affect to the nearby area. We monitor longitudinal resting-state brain activity and behavior change in this highly homogeneous white matter infarct rat model by using fcMRI and rat behavior test and try to find out the most behaviorally relevant fcMRI measurements. This project is still going on.

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