Metabolic and functional connectivity of the rat brain during resting state assessed by simultaneous [18F]FDG-PET/MR
Andre Thielcke1, Mario Amend1, Suril Gohel2, Bharat Biswal2, Bernd J. Pichler1, and Hans F. Wehrl1
1Department of Preclinical Imaging and Radiopharmacy, Werner Siemens Imaging Center, Eberhard Karls University of Tuebingen, Tuebingen, Germany, 2Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, United States
Recent
advancement in hardware and software has enabled researchers to study systems
level neuroscience using simultaneous PET/MRI. In this study, simultaneous PET/MR
was used to investigate resting state networks (RSN) in rats, comparing [18F]FDG
PET vs. BOLD-fMRI. RSNs such as default mode network (DMN) have been shown to
be disrupted in clinical populations. ICA and ROI-analysis was used to elucidate
the complementary nature between PET/MR and visualize brain connectivity. ICA PET
and MR data showed prominent RSNs. However, ROI-analysis illustrated different
connectivity between network-involved areas. This work suggests the
complimentary nature of metabolic connectivity mapping (Cometomics).
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