Longitudinal resting-state fMRI and 1H-MRS characterization in the mouse brain during development of a chronic pain state
David Bühlmann1,2, Joanes Grandjean1, Giovanna Diletta Ielacqua1, Jael Xandry3, and Markus Rudin1,3
1Institute for Biomedical Engineering, ETH and University of Zurich, Zurich, Switzerland, 2Neuroscience Center Zurich, Zurich, Switzerland, 3Institute of Pharmacology & Toxicology, University of Zurich, Zurich, Switzerland
We performed longitudinal resting-state fMRI
and single voxel 1H-MRS in a mouse model of chronic pain derived from bone
cancer. Linear mixed model analysis of independent components revealed significant
functional changes mostly in limbic but also cortical networks. These findings
were reproducible across strains and mirror findings from clinical studies on
chronic back pain patients. 1H-MRS in the affected ventral hippocampus yielded
significant decreases in glutamate, myo-inositol
and glycerylophosphorylcholine concentrations in tumor-animals as well as increased
glutamine levels. Given the translatability, these readouts could potentially
be used to evaluate novel treatments specifically for chronic pain.
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