The long-term reproducibility of stimulation and resting state fMRI in the mouse
Yi-Ching Lynn Ho1,2, Fiftarina Puspitasari1, and Kai-Hsiang Chuang1
1Singapore Bioimaging Consortium, Agency for Science, Technology & Research (A*STAR), Singapore, Singapore, 2Interdisciplinary Institute of Neuroscience & Technology (ZIINT), Zhejiang University, Hangzhou, China, People's Republic of
There is a need to evaluate
the long-term reproducibility of stimulation and resting state fMRI in the
mouse, given the technical challenges of mouse fMRI. We compared 2 sessions of
scans done between 3-9 weeks apart on 7 C57BL/6 mice. The intraclass
correlation (ICC) indicated significant absolute agreement for forepaw stimulation
fMRI results. Interhemispheric functional connectivity scores for a large subcortical
area like the CPu were also found to be reproducible, but in a small cortical
area like the S1FL, reproducibility did not reach significance. Possible
reasons include data coregistration mismatches due to distortion and
susceptibility artifacts.
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