Abstract #3749

Effects of Anesthesia on Functional Connectivity in Primary Somatosensory Cortex in Monkeys

Tung-Lin Wu^1,2, Arabinda Mishra¹, Feng Wang^1,3, Li Min Chen^1,3, and John C. Gore^1,2,3

¹Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, ²Biomedical Engineering, Vanderbilt University, Nashville, TN, United States, ³Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, United States

Low-frequency fluctuation of resting state functional MRI (rsfMRI) signals have been linked to changes in the spontaneous neuronal activity, but their relationships have not been established. Anesthesia is known to suppress neuronal activity. Thus, by examining the effects of different levels of anesthesia on changes in inter-regional functional connectivity and the power spectra, we will be able to assess the neuronal origins of the rsfMRI signals. We carried out live anesthetized squirrel monkey experiments that measure how low frequency fluctuations and inter-regional functional connectivity within a small local network (primary somatosensory cortex) vary as isoflurane levels are altered in a small range.

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