Abstract #3367

Cerebellar surface mapping using T1 and T2* relaxometry at ultrahigh-field MRI: from macroscale to microscale?

Yohan Boillat¹, Pierre-Louis Bazin², Kieran O'Brien^3,4, Mário João Fartaria de Oliveira^5,6, Guillaume Bonnier^1,6,7, Gunnar Krueger^6,8, Wietske van der Zwaag^1,9, and Cristina Granziera^1,6,7,10

¹Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ³Siemens Healthcare Pty Ltd., Brisbane, Australia, ⁴University of Queensland, St-Lucia, Australia, ⁵University of Lausanne, Lausanne, Switzerland, ⁶Advanced Clinical Imaging Technology Group, Siemens, Lausanne, Switzerland, ⁷Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, ⁸Healthcare Sector IM&WS S, Siemens Schweiz AG, Lausanne, Switzerland, ⁹Spinoza Centre for Neuroimaging, Amsterdam, Switzerland, ¹⁰Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States

The quantitative properties of the cerebellum were assessed by acquiring T₁ and T₂*contrasts at 7T and mapping these onto the cerebellar cortex. T₁ maps showed medial-lateral alternating stripes of different intensities while T₂* values were homogeneously distributed across the lobes. This study showed the heterogeneity of the cerebellar cortex in terms of tissue content, which in part parallels a well-established gene expression pattern.

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