Abstract #3366

Decrease in myelin water fraction of global white matter and white matter tracts in traumatic brain injury (TBI).

Bretta Russell-Schulz¹, Irene Vavasour², Jing Zhang², Alex MacKay^1,3, Shaun Porter⁴, Delrae Fawcett⁵, Ivan Torres⁵, William Panenka⁵, Lara Boyd⁶, and Naznin Virji-Babul⁴

¹UBC MRI Research Centre, Radiology, University of British Columbia, Vancouver, BC, Canada, ²Radiology, University of British Columbia, Vancouver, BC, Canada, ³Physics & Astronomy, University of British Columbia, Vancouver, BC, Canada, ⁴Physical Therapy, University of British Columbia, Vancouver, Canada, ⁵Psychiatry, University of British Columbia, Vancouver, Canada, ⁶Physical Therapy, University of British Columbia, Vancouver, BC, Canada

Chronic traumatic brain injury (TBI) was examined using myelin water fraction (MWF) in global white matter and tracts for subjects undergoing intensive cognitive training (Arrowsmith Program) compared to age and gender matched controls. MWF was significantly lower in TBI subjects and correlations were found between MWF and cognitive scores of fluid and crystallized ability. However, after 3 months of cognitive training no significant differences were found in MWF in TBI subjects.

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