Abstract #2391

Fast automatic voxel positioning with non-rigid registrations for improved between-subject consistency in MRS

Young Woo Park¹, Dinesh K. Deelchand², James M. Joers², Brian J. Soher³, Peter B. Barker⁴, HyunWook Park¹, Gülin Öz², and Christophe Lenglet²

¹School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea, Republic of, ²Department of Radiology, Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, MN, United States, ³Department of Radiology, Duke University Medical Center, Durham, NC, United States, ⁴Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

During the typical acquisition of single-voxel Magnetic Resonance Spectroscopy (MRS) the corresponding voxel-of-interest (VOI) must be selected manually, which induces some degree of variability. To address this, several automated VOI positioning methods, using rigid registration and aimed at follow-up scans of the same subject, have been proposed. This approach can be generalized to cross-subject scans, but with additional considerations for the anatomical variability. We hypothesized that non-rigid registration methods will minimize inter-subject variability in the tissue content of the VOI. Here, we present an analysis of registration strategies aimed at a reliable cross-subject automatic VOI positioning for MRS data acquisition.

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